The short answer is that world bosses respawn about every 6 hours.
Discover the mightyWorld Bosses in Diablo 4and advance your character through the end game. Level up your character, earn XP points, and acquire legendary gear by knowing theprecise locations and spawn times of these bosses.Prepare for epic battles and gather your party as we provide you with the essential information in this comprehensive guide. Explore the world of Diablo 4 with confidence, armed with the knowledge you need to face world bosses with the best chance of success.

Conquering Diablo 4’s world bosses grants valuable gear, including Legendary items, to all participants. Additionally, they are expected to play a vital role in advancing through theDiablo 4 Battle Passonce Season 1 is launched.
World Boss Respawn Timer in Diablo 4
Once you complete the main campaign, world bosses appear in Sanctuary at scheduled times. You’ll be notified on your map when a boss is about to spawn, marked with a unique symbol. A countdown timer of 15 to 30 minutes begins.
While theexact timesare not fully confirmed, Diablo 4 Life has created aD4 World Boss trackerthat will be updated. Also recently Blueberries.gg created aDiablo 4 World Boss Timer & Spawn Tracker

Spawn Locations (Approximate)
The 3 world bosses areAshava the Prestilent,Avarice, Gold CursedandWandering Death
Where to find
Ashava the Pestilent
Fields of Desecration, southwest of Hawezar
Avarice, the Gold Cursed
Seared Basin, northeast par of Kehjistan
Wandering Death
Crucible part of Fractured peaks in the east
According toMapgenieyou can find the locations below:
Conclusion
Master the challenges of Diablo 4’s world bosses for valuable rewards, including Legendary items. We will update our guide as more information comes out on D4 world bosses.